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SGX 523

Catalog #: 5356
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5356/10
5356/50
SGX 523 | CAS No. 1022150-57-7 | MET Receptor Inhibitors
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Description: Selective and potent c-MET kinase inhibitor

Chemical Name: 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

SGX 523 is a potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.

Technical Data

M.Wt:
359.41
Formula:
C18H13N7S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1022150-57-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SGX 523

The citations listed below are publications that use Tocris products. Selected citations for SGX 523 include:

2 Citations: Showing 1 - 2

  1. Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin.
    Authors: Bastounis Et al.
    Mol Biol Cell  2018;29:1571
  2. Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells.
    Authors: Ortega Et al.
    Mol Biol Cell  2017;28:2945

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