Sirtinol
Chemical Name: 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Purity: ≥98%
Biological Activity
Sirtinol is a cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
Jung-Hynes et al.
J.Biol.Chem., 2009;284:3823 -
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors.
Mai et al.
J.Med.Chem., 2005;48:7789 -
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.
Grozinger et al.
J.Biol.Chem., 2001;276:38837 -
A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells.
Kahyo et al.
J.Pharmacol.Sci., 2008;108:364
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Sirtinol
The citations listed below are publications that use Tocris products. Selected citations for Sirtinol include:
6 Citations: Showing 1 - 6
-
Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes.
Authors: Stoney Et al.
Glia 2016;64:425
-
Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.
Authors: M T Et al.
Cell Death Dis 2014;5:e1296
-
Activation of the stress proteome as a mechanism for small molecule therapeutics.
Authors: Kirby D Et al.
Hum Mol Genet 2012;21:4237-52
-
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α.
Authors: Balaiya Et al.
Mol Vis 2012;18:114
-
The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin.
Authors: María J Et al.
Diabetes 2011;60:1177-85
-
Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
Authors: Paffett Et al.
Vascul Pharmacol 2011;56:64
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Sirtinol
There are currently no reviews for this product. Be the first to review Sirtinol and earn rewards!
Have you used Sirtinol?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
