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SJF 8240

Catalog #: 7266 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7266/5
SJF 8240 | CAS No. 2230821-68-6 | Active Degraders
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Description: c-MET PROTAC®; also degrades exon-14-deleted c-MET

Chemical Name: N-(3-Fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Purity: ≥98%

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Biological Activity

SJF 8240 is a c-MET PROTAC® Degrader. Comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

c-MET antibodies validated for Western Blot also available: Catalog # AF276 and MAB5694.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1106.25
Formula:
C58H65F2N7O11S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2230821-68-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The advantages of targeted protein degradation over inhibition: an RTK case study.
    Burslem et al.
    Cell Chem.Biol., 2018;25:67

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