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SKA 121

Catalog #: 6398 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6398/5
6398/25
SKA 121 | CAS No. 1820708-73-3 | Ca2+-Activated Potassium Channel Activators
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Description: Positive allosteric modulator of KCa3.1 (IK) channels

Chemical Name: 5-Methylnaphth[2,1-d]oxazol-2-amine

Purity: ≥98%

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Biological Activity

SKA 121 is a positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50 = 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KV and NaV channels. Potentiates bradykinin-induced vasodilation ex vivo. Lowers mean arterial blood pressure in normotensive and hypertensive mice.

Technical Data

M.Wt:
198.23
Formula:
C12H10N2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1820708-73-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.
    Coleman et al.
    Mol.Pharmacol., 2014;86:342
  2. Vascular reactivity profile of novel KCa 3.1-selective positive-gating modulators in the coronary vascular bed.
    Oliván-Viguera et al.
    Basic Clin.Pharmacol.Toxicol., 2016;119:184

Product Datasheets

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