SKA 31
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Description: KCa3.1 (IK) and KCa2 (SK) channel activator
Chemical Name: Naphtho[1,2-d]thiazol-2-ylamine
Purity: ≥99%
Biological Activity
SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.Technical Data
M.Wt:
200.26
Formula:
C11H8N2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
40172-65-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.
Sankaranarayanan et al.
Mol.Pharmacol., 2009;75:281 -
Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.
Brahler et al.
Circulation, 2009;119:2323
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