Sodium 4-Phenylbutyrate
Chemical Name: 4-Phenylbutyric acid, sodium salt
Purity: ≥99%
Biological Activity
Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Sodium 4-Phenylbutyrate also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase.
Khan Z, Akhtar M, Ekstrom TJ.
Int J Mol Med -
Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection
C Seshadri, N Sedaghat, M Campo, G Peterson, RD Wells, GS Olson, DR Sherman, CM Stein, H Mayanja-Ki, A Shojaie, WH Boom, TR Hawn,
PLoS ONE, 2017;12(4):e0175844. -
Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways.
Kulkarni N, Yi Z, Huehnken C, Agerberth B, Gudmundsson G
Mol Immunol, 2015;63(2):530-9. -
Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells.
Appelskog et al.
Int.J.Oncol., 2004;24:1419 -
Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.
Ammerpohl et al.
Br.J.Cancer, 2007;96:73
Product Datasheets
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Citations for Sodium 4-Phenylbutyrate
The citations listed below are publications that use Tocris products. Selected citations for Sodium 4-Phenylbutyrate include:
2 Citations: Showing 1 - 2
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Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity.
Authors: Myszor Et al.
Sci Rep 2019;9:7114
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Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells.
Authors: Karadottir Et al.
Oncotarget 2015;3:e1483
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