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Sotalol hydrochloride

Catalog #: 0952
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0952/10
0952/50
Sotalol hydrochloride | CAS No. 959-24-0 | Non-selective Adrenergic beta Receptor Antagonists
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Description: β antagonist

Chemical Name: N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride

Purity: ≥99%

Product Details
Citations (3)
Supplemental Products
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Sotalol hydrochloride is a relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity.

Technical Data

M.Wt:
308.82
Formula:
C12H20N2O3S.HCl
Solubility:
Soluble to 50 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
959-24-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  3. Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'.
    Claudel and Touboul
    Pacing Clin.Electrophysiol., 1995;18:451
  4. Block of Iks by the diuretic agent indapamide modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol.
    Fiset et al.
    J.Pharmacol.Exp.Ther., 1997;283:148
  5. Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines.
    Uloth et al.
    J.Med.Chem., 1966;9:88
  6. Block of Iks by the diuretic agent indap. modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol.
    Fiset et al.
    J.Pharmacol.Exp.Ther., 1997;283:148

Product Datasheets

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Citations for Sotalol hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Sotalol hydrochloride include:

3 Citations: Showing 1 - 3

  1. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
    Authors: McKeithan Et al.
    Front Physiol  2017;8:766
  2. Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
    Authors: Kaya Et al.
    J Neurosci  2009;329:350
  3. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron  2007;54:599

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