Spadin
Purity: ≥95%
Biological Activity
Spadin is a potent TREK-1 channel blocker (IC50 = 71 nM). Enhances dorsal raphe nucleus 5-HT neurotransmission in mice. Induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects in mouse models of depression. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.
Mazella et al.
PLoS Biol., 2010;8:e1000355 -
Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept.
Borsotto et al.
Br.J.Pharmacol., 2015;172:771
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Citation for Spadin
The citations listed below are publications that use Tocris products. Selected citations for Spadin include:
1 Citation: Showing 1 - 1
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Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.
Authors: Fernandez-Fernandez Et al.
PLoS One 2018;13:e0199282
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