SQ 22536

Key Product Details

Product Description

SQ 22536 is an inhibitor of adenylyl cyclase (IC₅₀ = 1.4 μM). Inhibits PGE₁-stimulated increases in cAMP levels in intact human platelets. Cell permeable.

Product Specifications for SQ 22536

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SQ 22536

The following data is based on the product molecular weight 205.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	9.75 mL	48.73 mL	97.46 mL
2.5 mM	1.95 mL	9.75 mL	19.49 mL
5 mM	0.97 mL	4.87 mL	9.75 mL
25 mM	0.19 mL	0.97 mL	1.95 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 102 publications citing the usage of this product.

• Madhavan Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. 2018 PMID: 30046099
• Mei Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat.Methods. 2014 PMID: 24997607
• Harris Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 1979 PMID: 221552
• Hourani Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 2001 PMID: 11454656
• Fabbri Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 1991 PMID: 1669444

Product Documents for SQ 22536