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Streptozocin

Catalog #: 1621 Datasheet / COA / SDS
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1621/100
Streptozocin | CAS No. 18883-66-4 | Apoptosis Inducer Compounds
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Description: DNA alkylator; antitumor and induces diabetes
Alternative Names: Streptozotocin

Chemical Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose

Purity: ≥95%

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Biological Activity

Streptozocin is an antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.

Technical Data

M.Wt:
265.22
Formula:
C8H15N3O7
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
18883-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Alkylation of DNA in rat tissues following administration of streptozotocin.
    Bennett and Pegg
    Cancer Res., 1981;41:2786
  2. Steptozotocin: A review of its pharmacology, efficacy and toxicity.
    Weis
    Cancer Treat. Rep., 1982;66:427
  3. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
    NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman
    Nat. Biotechnol., 2020;0(0):.
  4. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells
    Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban
    Nat. Immunol., 2020;21(3):274-286.

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⚠ WARNING: This product can expose you to chemicals including Streptozocin (streptozotocin), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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