Stressin I
Purity: ≥95%
Biological Activity
Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.Technical Data
(Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior.
Bruchas et al.
PLoS One., 2009;4:e8528 -
Stressin1-A, a potent cortico. releasing factor receptor 1 (CRF1)-selective peptide agonist.
Rivier et al.
J.Med.Chem., 2007;50:1668 -
Receptor-selective cortico. releasing factor analogs.
Rivier et al.
Endocrin.Soc.Abstr., 2002;:P2-50
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Citations for Stressin I
The citations listed below are publications that use Tocris products. Selected citations for Stressin I include:
2 Citations: Showing 1 - 2
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Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
Authors: Silberman and Winder
Neuropharmacology 2013;70:316
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The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Authors: Land Et al.
J Neurosci 2008;28:407
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Exogenous application of various concentrations onto acute brain slices was used to examine CRF1 receptor modulation of GABA transmission in the central amygdala.
