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Strychnine hydrochloride

Catalog #: 2785 Datasheet / COA / SDS

Discontinued Product

2785 has been discontinued.
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Strychnine hydrochloride | CAS No. 1421-86-9 | Glycine Receptor Antagonists
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Description: Competitive glycine receptor antagonist

Chemical Name: Strychnidin-10-one hydrochloride

Purity: ≥98%

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Biological Activity

Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α7 receptors and non-competitive antagonism at α4β2 receptors.

Technical Data

M.Wt:
370.87
Formula:
C21H22N2O2.HCl
Solubility:
Soluble to 50 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
1421-86-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn.
    Jiang E, Yan X, Weng HR
    J. Neurochem., 2012;121(4):526-36.
  2. Strychnine: a potent competitive antagonist of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons.
    Mataubayashi et al.
    J.Pharmacol.Exp.Ther., 1998;284:904
  3. Glycine receptors: recent insights into their structural organization and functional diversity.
    Betz et al.
    J.Neurochem., 2006;67:1600

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