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SU 16f

Catalog #: 3304
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3304/10
3304/50
SU 16f | CAS No. 251356-45-3 | PDGF Receptor Inhibitors
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Description: Potent and selective PDGFRβ inhibitor

Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

Purity: ≥98%

Product Details
Citations (5)
Supplemental Products
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail.

For more information about how SU 16f may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

Technical Data

M.Wt:
386.44
Formula:
C24H22N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
251356-45-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SU 16f

The citations listed below are publications that use Tocris products. Selected citations for SU 16f include:

5 Citations: Showing 1 - 5

  1. PDGF inhibits BMP2-induced bone healing.
    Authors: Novak Et al.
    NPJ Regen Med  2023;8:3
  2. Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth.
    Authors: Chatterjee Et al.
    iScience  2019;19:388
  3. A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.
    Authors: Jiang Et al.
    Nat Commun  2017;8:15926
  4. Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells.
    Authors: Andersen Et al.
    Proc Natl Acad Sci U S A  2015;6:196
  5. Lymphatic endothelial cells support tumor growth in breast cancer.
    Authors: Lee Et al.
    Sci Rep  2014;4:5853

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