Swainsonine
Chemical Name: (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Biological Activity
Swainsonine is an inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II.
Tulsiani et al.
J.Biol.Chem., 1982;257:7936 -
The potential importance of swainsonine in therapy for cancers and immunology.
Olden et al.
Pharmacol.Ther., 1991;50:285 -
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine.
Sun et al.
Phytomedicine, 2007;14:353
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Citations for Swainsonine
The citations listed below are publications that use Tocris products. Selected citations for Swainsonine include:
3 Citations: Showing 1 - 3
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N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors.
Authors: Skrenkova Et al.
Front Mol Neurosci 2018;11:188
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Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells.
Authors: Tareen Et al.
Mol Ther 2014;22:575
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The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells.
Authors: Nacev Et al.
J Biol Chem 2011;286:44045
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