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T 5224

Catalog #: 7317 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7317/50
7317/10
T 5224 | CAS No. 530141-72-1 | AP-1 Inhibitors
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Description: Selective inhibitor of c-Fos/activator protein (AP)-1

Chemical Name: 5-[4-(Cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)methoxy]benzenepropanoic acid

Purity: ≥98%

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Biological Activity

T 5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It inhibits the DNA-binding and transactivation activities of AP-1, without affecting the activity of ATF2, C/EBPα, NF-κB/p65, MyoD, and Sp1 in vitro. In a mouse model, T 5224 prevents type II collagen-induced arthritis by reducing inflammatory cytokines (including interleukin 1β) and matrix-degrading MMPs.

Technical Data

M.Wt:
517.53
Formula:
C29H27NO8
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
530141-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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