t-TUCB
Chemical Name: 4-[[trans-4-[[[[4-(Trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]benzoic acid
Purity: ≥98%
Biological Activity
t-TUCB is a potent soluble epoxide hydrolase (sEH) Inhibitor (IC50 = 0.9 nM). Enhances hepatic eNOS phosphorylation and NO release. Exhibits antihypertensive and cardioprotective actions in cirrhotic rat models. Suppress the activation of HSCs and reduce hepatic fibrosis through inhibition of NF-κB/IκBα signaling. Anti-inflammatory and antinociceptive.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Orally bioavailable potent soluble epoxide hydrolase inhibitors.
Hwang et al.
J.Med.Chem., 2007;50:3825 -
Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis.
Deng et al.
Prostaglandins Other Lipid Mediat., 2017;131:67
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