Home / DNA, RNA and Protein Synthesis Compounds / T4

T4

Catalog #: 7054 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7054/10
7054/50
T4 | CAS No. 785708-33-0 | DNA, RNA and Protein Synthesis Compounds
1 Image
Description: Modulator of alternative polyadenylation; inhibits rod photoreceptor gene expression via Nr2e3

Chemical Name: 6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl)]quinazolin-4(3H)-one

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

T4 is a modulator of alternative polyadenylation (APA) (IC50 values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively). T4 promotes distal-to-proximal APA usage in multiple transcripts, using distinctive A-rich motifs through autoregulated PABPN1 signaling. T4 exhibits no inhibitory activity against a panel of 414 kinases. T4 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. T4 inhibits rod photoreceptor gene expression via Nr2e3 in a luciferase-based assay (IC50 = 0.07 μM).

Technical Data

M.Wt:
377.44
Formula:
C22H23N3O3
Solubility:
Soluble to 2 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
785708-33-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for T4

There are currently no reviews for this product. Be the first to review T4 and earn rewards!

Have you used T4?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.