TAPI 2

Catalog #: 6013
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6013/1

1 Image

Description: ADAM-17 (TACE) and MMP inhibitor

Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide

Purity: ≥95%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TAPI 2 is an ADAM-17 (TACE) and MMP inhibitor (K_i = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.

This product is typically reconstituted in water.

Technical Data

M.Wt:

415.54

Formula:

C₁₉H₃₇N₅O₅

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

689284-12-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

CXCR4 Accelerates Osteoclastogenesis Induced by Non-Small Cell Lung Carcinoma Cells Through Self-Potentiation and VCAM1 Secretion
T Liao, W Chen, J Sun, Y Zhang, X Hu, S Yang, H Qiu, S Li, T Chu
Cell. Physiol. Biochem., 2018;50(3):1084-1099.
Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.
Moss et al.
Anal.Biochem., 2007;366:144
A disintegrin and metalloproteinase domain 17 regulates colorectal cancer stem cells and chemosensitivity via notch1 signaling.
Wang et al.
Stem Cells Transl.Med., 2016;5:331

Product Datasheets

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for TAPI 2

The citations listed below are publications that use Tocris products. Selected citations for TAPI 2 include:

2 Citations: Showing 1 - 2

Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma.
Authors: Jian Et al.
Cancer Immunol Res 2020;8:1554-1567
A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation.
Authors: Hui Et al.
Mol Biol Cell 2014;25:3798-812

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