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TBIA

Catalog #: 7788 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7788/10
TBIA | DNA, RNA and Protein Synthesis Compounds
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Description: Bivalent SHAPE cross-linking reagent
Alternative Names: trans-bis-isatoic anhydride

Chemical Name: 1,6-Dihydrobenzo[1,2-d:4,5-d']bis([1,3]oxazine)-2,4,7,9-tetraone

Purity: ≥95%

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Biological Activity

TBIA (trans-bis-isatoic anhydride) is a bifunctional SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) chemical cross-linking reagent. TBIA has two electrophilic isatoic anhydride moieties, both of which can react with the 2'-OH group in nucleotides adjacent to and distant from the primary RNA sequence. TBIA is used in SHAPE-JuMP (-juxtaposed merged pairs) a technique for exploring RNA tertiary structure proximity on large RNAs, and higher-order RNA-RNA interactions at nanometer resolution.

Technical Data

M.Wt:
248.15
Formula:
C10H4N2O6
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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