TC-E 5007
Discontinued Product
Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride
Purity: ≥98%
Biological Activity
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Lankas et al.
Diabetes, 2005;54:2988 -
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor.
Wu et al.
Biochem.Pharmacol., 2009;78:203 -
Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates.
Van der Veken et al.
J.Med.Chem., 2007;50:5568
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