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TC-G 1001

Catalog #: 4879 Datasheet / COA / SDS
Catalog # Availability Size / Price
4879/10 Contact your distributor for availability.10 mg / Please Inquire
4879/50 Contact your distributor for availability.50 mg / Please Inquire
TC-G 1001 | CAS No. 494191-73-0 | Orphan 7-TM Receptor Agonists
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Description: GPR35 agonist; more potent than zaprinast (Cat. No. 0947)

Chemical Name: 4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid

Purity: ≥98%

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Biological Activity

TC-G 1001 is a GPR35 agonist (pEC50 values are 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays respectively). Displays 1000-fold greater potency at human GPR35 receptors relative to mouse and rat GPR35 orthologs in an IP1 accumulation assay. More potent than zaprinast (Cat. No. 0947).

Technical Data

M.Wt:
342.34
Formula:
C17H11FN2O3S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
494191-73-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput identification and characterization of novel, species-selective GPR35 agonists.
    Neetoo-Isseljee et al.
    J.Pharmacol.Exp.Ther., 2013;344:568

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