TC OT 39
Chemical Name: (2S)-N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide
Purity: ≥97%
Biological Activity
TC OT 39 is a potent non-peptide oxytocin receptor partial agonist (EC50 values are 33 nM and 850 nM for the oxytocin receptor and V2 vasopressin receptor respectively). Also a V1a vasopressin receptor antagonist (Ki = 330 nM). Active in vivo in a rat model of uterine response.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxyt. receptor agonist.
Frantz et al.
J.Med.Chem., 2010;53:1546 -
Non-peptide oxyt. agonists.
Pitt et al.
Bioorg.Med.Chem.Lett., 2004;14:4585
Product Datasheets
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