TC-S 7005
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine
Purity: ≥98%
Biological Activity
TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM). Shows selectivity for PLK2 over PLK3 and PLK1 (IC50 values are 24 and 214 nM respectively). Induces mitotic arrest and cell death in HCT 116 colorectal cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.
Hanan et al.
Bioorg.Med.Chem.Lett., 2008;18:5186
Product Datasheets
Citation for TC-S 7005
The citations listed below are publications that use Tocris products. Selected citations for TC-S 7005 include:
1 Citation: Showing 1 - 1
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Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
Authors: Arimoto Et al.
Nat Commun 2023;14:251
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