TCS PrP Inhibitor 13
Discontinued Product
Chemical Name: 2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one
Purity: ≥98%
Biological Activity
TCS PrP Inhibitor 13 is an antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Cellular prion protein (PrPC) in the development of Merlin-deficient tumours.
Provenzano et al.
Oncogene., 2017;36:6132 -
New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation.
Kimata et al.
J.Med.Chem., 2007;50:5053
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for TCS PrP Inhibitor 13
The citations listed below are publications that use Tocris products. Selected citations for TCS PrP Inhibitor 13 include:
2 Citations: Showing 1 - 2
-
Augmented cAMP Signaling by Co-Administration of Resveratrol and Curcumin: A Cellular Biosensor Kinetic Assessment.
Authors: Safavifar Et al.
Iran J Public Health 2019;48:1310
-
Cellular prion protein (PrPC) in the development of Merlin-deficient tumours.
Authors: Provenzano Et al.
Oncogene. 2017;
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for TCS PrP Inhibitor 13
There are currently no reviews for this product. Be the first to review TCS PrP Inhibitor 13 and earn rewards!
Have you used TCS PrP Inhibitor 13?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
