TDZD 8
Chemical Name: 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
Purity: ≥98%
Biological Activity
TDZD 8 is a selective non-ATP competitive inhibitor of GSK 3β (IC50 = 2 μM); thiadiazolidinone deriviative. Does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. Reduces severity of L-dopa-induced dyskinesia in a Parkinson's disease in vivo model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease.
Martinez et al.
J.Med.Chem., 2002;45:1292 -
Inhibition of Glycogen Synthase Kinase-3β (GSK-3�) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats.
Xie et al.
Sci.Rep., 2016;6:23527
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Citation for TDZD 8
The citations listed below are publications that use Tocris products. Selected citations for TDZD 8 include:
1 Citation: Showing 1 - 1
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Glycogen synthase kinase-3 inhibition rescues sex-dependent contextual fear memory deficit in human immunodeficiency virus-1 transgenic mice.
Authors: Coleen M Et al.
Br J Pharmacol 2020;177:5658-5676
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