Home / Adrenergic alpha-1 Receptor Antagonists / Terazosin hydrochloride

Terazosin hydrochloride

Catalog #: 1506
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1506/50
Terazosin hydrochloride | CAS No. 63074-08-8 | Adrenergic alpha-1 Receptor Antagonists
1 Image
Description: α1 antagonist; PGK1 activator

Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Terazosin hydrochloride is a selective α1 antagonist. Increases phosphoglycerate kinase 1 (PGK1) activity (Kd = 2.9 μM). Upregulates glucose metabolism and increases ATP production. In an in vitro model of GI disease, terazosin reduces inflammation and protects against oxidative damage. Neuroprotective in in vivo models of ALS and Parkinson's Disease. Antihypertensive following oral or intravenous administration in vivo.

Technical Data

M.Wt:
423.9
Formula:
C19H25N5O4.HCl
Solubility:
Soluble to 20 mM in water with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
63074-08-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacology of tera.
    Kyncl
    Am.J.Med., 1986;80:12
  2. Actions of tera. and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro.
    Hancock et al.
    J.Recept.Signal Transduct.Res., 1995;15:863
  3. Comparison of displacemental potencies of tera. enantiomers for α1-adrenoceptor subtypes.
    Maruyama et al.
    Biol.Pharm.Bull., 1994;17:1126

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Terazosin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Terazosin hydrochloride include:

2 Citations: Showing 1 - 2

  1. The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
    Authors: Kahn Et al.
    EMBO Mol Med  2016;8:511
  2. Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
    Authors: Bucher Et al.
    J Cereb Blood Flow Metab  2014;34:1128

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Terazosin hydrochloride

There are currently no reviews for this product. Be the first to review Terazosin hydrochloride and earn rewards!

Have you used Terazosin hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.