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Tertiapin LQ

Catalog #: 4339 Datasheet / COA / SDS

Discontinued Product

4339 has been discontinued.
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Tertiapin LQ
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Description: Selective Kir1.1 blocker; derivative of tertiapin-Q (Cat. No. 1316)
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Biological Activity

Tertiapin LQ is a blocker of Kir1.1 channels; displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Derivative of tertiapin-Q (Cat. No. 1316).

Technical Data

M.Wt:
2428.03
Formula:
C106H179N33O24S4
Sequence:
ALCNCNRIIIPLQCWKKCGKK

(Modifications: Disulfide bridge between 3 - 14, 5 - 18, Lys-21 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in 20% acetonitrile / water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels.
    Ramu et al.
    Proc.Natl.Acad.Sci.USA, 2008;105:10774

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