Thiamet G

Key Product Details

Product Description

Thiamet G is a potent, selective inhibitor of O-GlcNAcase (K_i = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

Product Specifications for Thiamet G

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Thiamet G

The following data is based on the product molecular weight 248.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.05 mL	40.27 mL	80.55 mL
2.5 mM	1.61 mL	8.05 mL	16.11 mL
5 mM	0.81 mL	4.03 mL	8.05 mL
25 mM	0.16 mL	0.81 mL	1.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 27 publications citing the usage of this product.

• Zhu Pharmacological inhibition of O-GlcNAcase enhances autophagy in brain through an mTOR-independent pathway ACS Chem.Neurosci. 2018 PMID: 29460617
• Yuzwa A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 2008 PMID: 18587388

Product Documents for Thiamet G