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Threo-methylphenidate hydrochloride

Catalog #: 1812
3 Citations Datasheet / COA / SDS

Discontinued Product

1812 has been discontinued.
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Threo-methylphenidate hydrochloride | CAS No. 298-59-9 | Dopamine Transporter Inhibitors
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Description: Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
Alternative Names: Ritalin

Chemical Name: Threo-methyl α-Phenyl-2-piperidineacetate hydrochloride

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Threo-methylphenidate hydrochloride is a psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo.

Technical Data

M.Wt:
269.77
Formula:
C14H19NO2.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
298-59-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Methylphenidate (Ritalin): behavioral studies in the rat.
    Askenasy et al.
    Int.J.Neurosci., 2007;117:757
  2. Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects.
    Leonard et al.
    Human Psychopharm., 2004;19:151

Product Datasheets

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Citations for Threo-methylphenidate hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Threo-methylphenidate hydrochloride include:

3 Citations: Showing 1 - 3

  1. Pharmacological Chaperones of the DA Transporter Rescue DA Transporter Deficiency Syndrome Mutations in Heterologous Cells.
    Authors: Beerepoot Et al.
    J Biol Chem  2016;291:22053
  2. Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.
    Authors: Poulin Et al.
    Mol Pharmacol  2014;86:378
  3. Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.
    Authors: Parker Et al.
    PLoS One  2014;231:2671

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