Tiotropium bromide
Chemical Name: (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
Purity: ≥98%
Biological Activity
Tiotropium bromide is a potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro (IC50 = 0.17 nM). Induces smooth muscle relaxation and bronchodilation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effect of Ba 679 BR, a novel long-acting anticholin. agent, on cholinergic neurotransmission in guinea pig and human airways.
Takahashi et al.
Am.J.Respir.Crit.Care Med., 1994;150:1640 -
Bronchoprotection by olodaterol is synergistically enhanced by tiotr. in a guinea pig model of allergic asthma.
Smit et al.
J.Pharmacol.Exp.Ther., 2014;348:303 -
Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrr.
Ogoda et al.
J.Pharm.Sci., 2011;115:374
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