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TMPH hydrochloride

Catalog #: 2438
2 Citations Datasheet / COA / SDS

Discontinued Product

2438 has been discontinued.
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TMPH hydrochloride | CAS No. 849461-91-2 | Additional Nicotinic Receptor Antagonists
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Description: Neuronal nAChR antagonist

Chemical Name: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

TMPH hydrochloride is a potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). Displays little inhibition of muscle-type (α1β1γδ) or α7 receptors.

Technical Data

M.Wt:
305.88
Formula:
C16H31NO2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
849461-91-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Florida Research Foundation Inc.

Product Datasheets

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Citations for TMPH hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for TMPH hydrochloride include:

2 Citations: Showing 1 - 2

  1. Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine.
    Authors: Pinnock Et al.
    J Biomed Sci  2015;9:30
  2. Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.
    Authors: Peng Et al.
    Mol Pharmacol  2013;84:459

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