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Tomoxetine hydrochloride

Catalog #: 2011
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2011/10
2011/50
Tomoxetine hydrochloride | CAS No. 82248-59-7 | Adrenergic Transporter Inhibitors
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Description: Potent and selective noradrenalin re-uptake inhibitor
Alternative Names: Atomoxetine,LY 139603

Chemical Name: (R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride

Purity: ≥99%

Product Details
Citations (5)
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Biological Activity

Tomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.

Technical Data

M.Wt:
291.82
Formula:
C17H21NO.HCl
Solubility:
Soluble to 50 mM in water with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
82248-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for Tomoxetine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Tomoxetine hydrochloride include:

5 Citations: Showing 1 - 5

  1. Methylphenidate and atomox. inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.
    Authors: Achterberg Et al.
    Psychopharmacology (Berl)  2015;35:161
  2. Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
    Authors: Conley Et al.
    J Neurosci  2015;352:53
  3. Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.
    Authors: Finnema Et al.
    Toxins (Basel)  2015;18
  4. Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish.
    Authors: Parker Et al.
    Int J Neuropsychopharmacol  2014;231:2671
  5. Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine.
    Authors: Kobayashi Et al.
    Neuropsychopharmacology  2010;35:1560

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