Topotecan hydrochloride
Chemical Name: 10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride
Purity: ≥98%
Biological Activity
Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.
Schellens et al.
Br.J.Cancer, 1996;73:1268 -
A chemical screen identifies the chemotherapeutic drug topo. as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma.
Sottile et al.
Oncotarget., 2012;3:535
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Citations for Topotecan hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Topotecan hydrochloride include:
6 Citations: Showing 1 - 6
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Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma.
Authors: Jen Q Et al.
Cancers (Basel) 2022;14
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Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.
Authors: Michael G Et al.
Cancer Res 2021;81:400-413
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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
Authors: Balmus Et al.
Nat Commun 2019;10:87
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Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
Authors: Florea Et al.
Oncotarget 2017;8:22876
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Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.
Authors: Martin Et al.
Cell Chem Biol 2017;24:624-634.e3
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Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.
Authors: Pearson Et al.
Int J Mol Med 2016;7:11173
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