TPPB
Chemical Name: (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide
Purity: ≥98%
Biological Activity
TPPB is a high affinity and cell permeable protein kinase C activator (Ki =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Reversal of diabetes with Ins-producing cells derived in vitro from human pluripotent stem cells.
Rezania et al.
Nat.Biotechnol., 2014;32:1121 -
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
Chen et al.
Nat.Chem.Biol., 2009;5:258 -
New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα.
Kozikowski et al.
J.Med.Chem., 2003;46:364 -
Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman
Nat. Biotechnol., 2020;0(0):.
Product Datasheets
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Citations for TPPB
The citations listed below are publications that use Tocris products. Selected citations for TPPB include:
6 Citations: Showing 1 - 6
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Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians.
Authors: Robert G Et al.
Cells 2022;11
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Generation of insulin-producing pancreatic β cells from multiple human stem cell lines.
Authors: Kristina G Et al.
Nat Protoc 2021;16:4109-4143
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Bioinformatic Analyses of miRNA-mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation.
Authors: Kenichiro Et al.
Biomedicines 2020;8
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Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells.
Authors: Leonardo Et al.
Nat Biotechnol 2020;38:460-470
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A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Authors: Yang Et al.
Cell Stem Cell 2020;27:125
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Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction.
Authors: Rudolf Et al.
Cell Rep Med 2020;1:100097
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