Trolox
Chemical Name: 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
Purity: ≥98%
Biological Activity
Trolox is an antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Also inhibits ferroptosis. Commonly used antifade reagent in live cell imaging; suppresses blinking and photobleaching. Cell-permeable and water soluble.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of protein radical reactions of ferrylmyoglobin by the water-soluble analog of vitamin E, Trolox C.
Giulivi et al.
Arch.Biochem.Biophys., 1993;303:152 -
Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling.
Lee et al.
J.Biol.Chem., 2009;284:13725 -
Ferroptosis: process and function.
Xie et al.
Cell.Death.Differ, 2016;23:369 -
On the mechanism of Trolox as antiblinking and antibleaching reagent.
Cordes et al.
J.Am.Chem.Soc., 2009;131:5018
Product Datasheets
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Citations for Trolox
The citations listed below are publications that use Tocris products. Selected citations for Trolox include:
2 Citations: Showing 1 - 2
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Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity.
Authors: Yi-Sook Et al.
Antioxidants (Basel) 2020;9
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Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels.
Authors: Miriam Et al.
Cell Rep 2020;30:3250-3260.e7
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