TRPC6-PAM-C20
Chemical Name: 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
Purity: ≥98%
Biological Activity
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels.
Häfner et al.
Cell Calcium, 2019;78:26
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Citation for TRPC6-PAM-C20
The citations listed below are publications that use Tocris products. Selected citations for TRPC6-PAM-C20 include:
1 Citation: Showing 1 - 1
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New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice.
Authors: Anastasia Et al.
Int J Mol Sci 2022;23
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