Home / Casein Kinase 2 Inhibitors / TTP 22

TTP 22

Catalog #: 4432
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4432/10
4432/50
TTP 22 | CAS No. 329907-28-0 | Casein Kinase 2 Inhibitors
1 Image
Description: High affinity, selective CK2 inhibitor

Chemical Name: 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki = 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μM).

Technical Data

M.Wt:
330.42
Formula:
C16H14N2O2S2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
329907-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2.
    Golub et al.
    Eur.J.Med.Chem., 2011;46:870
  2. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
    TW Kim, J Piao, SY Koo, S Kriks, SY Chung, D Betel, ND Socci, SJ Choi, S Zabierowsk, BN Dubose, EJ Hill, EV Mosharov, S Irion, MJ Tomishima, V Tabar, L Studer
    Cell Stem Cell, 2021;28(2):343-355.e5.

Product Datasheets

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Citations for TTP 22

The citations listed below are publications that use Tocris products. Selected citations for TTP 22 include:

2 Citations: Showing 1 - 2

  1. The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis.
    Authors: Till S Et al.
    Commun Biol  2021;4:336
  2. Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures.
    Authors: Didier Y R Et al.
    Elife  2021;10

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