Home / Other Transferase Inhibitors / Tunicamycin

Tunicamycin

Catalog #: 3516
26 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3516/10
Tunicamycin | CAS No. 11089-65-9 | Other Transferase Inhibitors
1 Image
Description: Antibiotic; GlcNAc phosphotransferase inhibitor

Chemical Name: Tunicamycin from Streptomyces sp.

Purity: ≥98%

Product Details
Citations (26)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Tunicamycin is an antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows:
  • Homolog A, n=8, C37H60N4O16, molecular weight = 816.90
  • Homolog B, n=9, C38H62N4O16, molecular weight = 830.93
  • Homolog C, n=10, C39H64N4O16, molecular weight = 844.95
  • Homolog D, n=11, C40H66N4O16, molecular weight = 858.99
The composition of this product will vary from batch to batch and can be found on the relevant certificate of analysis.

Technical Data

M.Wt:
844.95
Formula:
C39H64N4O16 (tunicamycin C, n=10)
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
11089-65-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Tunicamycin

The citations listed below are publications that use Tocris products. Selected citations for Tunicamycin include:

26 Citations: Showing 1 - 10

  1. Staufen Impairs Autophagy in Neurodegeneration.
    Authors: Daniel R Et al.
    Ann Neurol  2023;93:398-416
  2. Soluble Klotho protects against glomerular injury through regulation of ER stress response.
    Authors: Mikhail Et al.
    Commun Biol  2023;6:208
  3. Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches.
    Authors: François Et al.
    Nat Commun  2023;14:3028
  4. Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.
    Authors: Jochen H M Et al.
    Nat Commun  2023;14:2132
  5. Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin.
    Authors: Yatrik M Et al.
    Proc Natl Acad Sci U S A  2023;120:e2212644120
  6. Integrated stress response restricts macrophage necroptosis.
    Authors: Parimal Et al.
    Life Sci Alliance  2022;5
  7. The Sec61 translocon is a therapeutic vulnerability in multiple myeloma.
    Authors: Jean-Christophe Et al.
    EMBO Mol Med  2022;14:e14740
  8. Systemic lipolysis promotes physiological fitness in Drosophila melanogaster.
    Authors: Lu Et al.
    Aging (Albany NY)  2022;14:6481-6506
  9. Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers.
    Authors: Andrew V Et al.
    Cancer Res  2021;81:5325-5335
  10. A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.
    Authors: Troy Et al.
    JCI Insight  2021;6
  11. Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation.
    Authors: Ho-Chou Et al.
    Nat Metab  2021;3:513-522
  12. Endoplasmic Reticulum Stress in Subepithelial Myofibroblasts Increases the TGF-β1 Activity That Regulates Fibrosis in Crohn's Disease.
    Authors: Chao Et al.
    Inflamm Bowel Dis  2020;26:809-819
  13. Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle.
    Authors: Catarina Et al.
    J Cell Physiol  2020;235:7370-7382
  14. MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia.
    Authors: Nathalie Et al.
    Nat Commun  2020;11:6087
  15. Probing natural variation of IRE1 expression and endoplasmic reticulum stress responses in Arabidopsis accessions.
    Authors: Karolina M Et al.
    Sci Rep  2020;10:19154
  16. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress.
    Authors: Shemorry Et al.
    Elife  2019;8
  17. A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells.
    Authors: Zhang Et al.
    J Biol Chem  2019;
  18. ONC201 kills breast cancer cells in vitro by targeting mitochondria.
    Authors: Greer Et al.
    Oncotarget  2018;9:18454
  19. Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death.
    Authors: Hossain Et al.
    Oncotarget  2018;9:11707
  20. Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
    Authors: Peter Et al.
    Mol Cell  2018;71:629-636.e5
  21. High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect.
    Authors: Nathalie Et al.
    Elife  2018;7
  22. N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors.
    Authors: Skrenkova Et al.
    Front Mol Neurosci  2018;11:188
  23. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.
    Authors: Bajikar Et al.
    Dev Cell  2017;43:418
  24. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer.
    Authors: Gupta Et al.
    Oncogene  2016;35:5860
  25. CHOP and caspase 3 induction underlie glioblastoma cell death in response to endoplasmic reticulum stress.
    Authors: Quincy A Et al.
    Exp Ther Med  2012;3:487-492
  26. ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.
    Authors: Deldicque Et al.
    PLoS One  2011;6:e20993

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Tunicamycin

There are currently no reviews for this product. Be the first to review Tunicamycin and earn rewards!

Have you used Tunicamycin?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.