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TWS 119

Catalog #: 7405 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7405/10
TWS 119 | CAS No. 601514-19-6 | GSK-3 Inhibitors
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Description: Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol

Purity: ≥97%

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Biological Activity

TWS 119 is a potent inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). TWS 119 inhibits both GSK3α and GSK3β in vitro (IC50 = 88 nM and 410 nM, respectively). TWS 119 induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells at 400 nM. TWS 119 enhances the proliferation and survival of γδ T-cells, and induces differentiation of CD8+ T cells towards a stem cell-like memory T cell phenotype at 2.5 μM.

Technical Data

M.Wt:
318.33
Formula:
C18H14N4O2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
601514-19-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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