Tyrphostin B44, (-) enantiomer

Name: Tyrphostin B44, (-) enantiomer
Brand: Tocris Bioscience
SKU: 0578

Catalog #: 0578 Datasheet / COA / SDS

Discontinued Product

0578 has been discontinued.

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Tyrphostin B44, (-) enantiomer | CAS No. 133550-32-0 | EGF Receptor Inhibitors

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Description: EGFR-kinase inhibitor

Chemical Name: (R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide

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Product Details

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC₅₀ = 0.4 μM), more active than the (+) enantiomer. Selective over ErbB2.

(+)-enantiomer also available.

Technical Data

M.Wt:

308.34

Formula:

C₁₈H₁₆N₂O₃

Solubility:

Soluble to 30 mM in DMSO

Storage:

Desiccate at +4°C

CAS No:

133550-32-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

(+)-enantiomer Available

Background References

Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Gazit et al.
J.Med.Chem., 1991;34:1896

Product Datasheets

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SDS

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