Home / Phospholipase Inhibitors / U 73343

U 73343

Catalog #: 4133
20 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4133/10
4133/50
U 73343 | CAS No. 142878-12-4 | Phospholipase Inhibitors
1 Image
Description: Analog of U 73122 (Cat. No. 1268)

Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione

Purity: ≥98%

Product Details
Citations (20)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

U 73343 is an analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.

Active Analog also available.

Technical Data

M.Wt:
466.66
Formula:
C29H42N2O3
Solubility:
Soluble to 10 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
142878-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1

    J Neurosci, 2016;36(18):5055-70.
  2. Platelet Ca(2+) responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca(2+) stores.
    Fung CY, Jones S, Ntrakwah A, Naseem KM, Farndale RW, Mahaut-Smith MP
    Blood, 2012;119(15):3613-21.
  3. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
    Nature, 2012;492(7427):123-7.
  4. IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes
    P Atakpa, NB Thillaiapp, S Mataragka, DL Prole, CW Taylor
    Cell Rep, 2018;25(11):3180-3193.e7.
  5. Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow.
    Berven and Barritt
    Biochem.Pharmacol., 1995;49:1373
  6. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell.
    Muto et al.
    J.Pharmacol.Exp.Ther., 1997;282:1379
  7. Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT.
    Kataoka et al.
    J.Neurochem., 2009;108:115
  8. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
    Ma et al.
    J.Pharmacol.Exp.Ther., 2009;328:409

Product Datasheets

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Citations for U 73343

The citations listed below are publications that use Tocris products. Selected citations for U 73343 include:

20 Citations: Showing 1 - 10

  1. Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses.
    Authors: Samir Et al.
    iScience  2023;26:106707
  2. Regulation of Focal Adhesion Dynamics and Cell Migration by PLC/PI3K-Mediated Metabolism of PtdIns (4,5) P2 in a Breast Cancer Cell Line.
    Authors: Dhurgham Et al.
    Rep Biochem Mol Biol  2022;11:270-281
  3. Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
    Authors: Babola Et al.
    ELife  2020;9:e52160
  4. Novel metabolic role for BDNF in pancreatic β-cell insulin secretion.
    Authors: Lino Et al.
    Nat Commun  2020;11:1950
  5. A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila.
    Authors: Thomas A Et al.
    Nature  2019;574:559-564
  6. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.
    Authors: Giovanni Et al.
    Cell  2019;177:1280-1292.e20
  7. IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes.
    Authors: Atakpa Et al.
    Cell Rep  2018;25:3180
  8. A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion.
    Authors: Rajan Et al.
    Dev Cell  2017;43:83
  9. Dust particles-induced intracellular Ca2+ signaling and reactive oxygen species in lung fibroblast cell line MRC5.
    Authors: Jeong Hee Et al.
    Korean J Physiol Pharmacol  2017;21:327-334
  10. Detachment of surface membrane invagination systems by cationic amphiphilic drugs.
    Authors: Osman Et al.
    PLoS One  2016;6:18536
  11. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  12. The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells.
    Authors: Yoon Et al.
    Sci Rep  2015;2015:843024
  13. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
    Authors: Montalbano Et al.
    PLoS One  2015;10:e0140369
  14. DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    J Cereb Blood Flow Metab  2015;10:e0124986
  15. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  16. Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.
    Authors: Ruisanchez Et al.
    FASEB J  2014;28:880
  17. A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.
    Authors: Brenner Et al.
    Pain  2014;155:2124
  18. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.
    Authors: Zhao
    J Neurophysiol  2014;111:1008
  19. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  20. Phosphatidylinositol (4,5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neurons.
    Authors: Zhen Et al.
    Mol Pharmacol  2009;76:1349-59

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