UAMC 00039 dihydrochloride
Discontinued Product
Chemical Name: (2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
Purity: ≥98%
Biological Activity
UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Orally available.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?
Van Goethem et al.
J.Med.Chem., 2011;54:5737 -
Dipeptidyl peptidase 8/9-like activity in human leukocytes.
Maes et al.
J.Leukoc.Biol., 2007;81:1252
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Citation for UAMC 00039 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for UAMC 00039 dihydrochloride include:
1 Citation: Showing 1 - 1
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Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
Authors: Klein Et al.
Neuron 2017;95:281
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