UB 165 fumarate
Discontinued Product
Chemical Name: 2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate
Purity: ≥99%
Biological Activity
UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]DA release.
Cao et al.
Neuropharmacology, 2005;48:72 -
UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of DA release from rat striatal synaptosomes.
Sharples et al.
J.Neurosci., 2000;20:2783 -
Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid.
Wright et al.
Bioorg.Med.Chem.Lett., 1997;7:2867
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