Home / Fatty Acid Amide Hydrolase (FAAH) Inhibitors / URB 597

URB 597

Catalog #: 4612
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4612/10
4612/50
URB 597 | CAS No. 546141-08-6 | Fatty Acid Amide Hydrolase (FAAH) Inhibitors
1 Image
Description: Potent and selective FAAH inhibitor

Chemical Name: Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester

Purity: ≥99%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

URB 597 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

Technical Data

M.Wt:
338.4
Formula:
C20H22N2O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
546141-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Reconstitution Calculator

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Citations for URB 597

The citations listed below are publications that use Tocris products. Selected citations for URB 597 include:

6 Citations: Showing 1 - 6

  1. Neurexin1α differentially regulates synaptic efficacy within striatal circuits.
    Authors: Marc V Et al.
    Cell Rep  2021;34:108773
  2. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
    Authors: Morena Et al.
    Neuropharmacology  2016;111:59
  3. Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine.
    Authors: Vilela Et al.
    J Neurosci  2015;2015:523418
  4. Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
    Authors: Sardinha Et al.
    Mediators Inflamm  2014;2014:978678
  5. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
    Authors: Butti Et al.
    Brain  2012;135:3320
  6. The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
    Authors: Hamtiaux Et al.
    BMC Cancer  2012;12:92

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