Urotensin II (human)

Name: Urotensin II (human)
Brand: Tocris Bioscience
SKU: 1642
Price: 373 USD

Catalog #: 1642 Datasheet / COA / SDS

Discontinued Product

1642 has been discontinued.

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Description: Endogenous vasoactive agonist for the UT receptor

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Biological Activity

Urotensin II (human) is a potent endogenous peptide agonist for the urotensin-II receptor (EC₅₀ = 0.1 nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo, effects which vary between species. Also has been shown to mediate bronchoconstriction.

Technical Data

M.Wt:

1388.57

Formula:

C₆₄H₈₅N₁₃O₁₈S₂

Sequence:

ETPDCFWKYCV

(Modifications: Disulfide bridge between 5 - 10)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

251293-28-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord.
Coulouarn et al.
Proc.Natl.Acad.Sci.U.S.A., 1998;95:15803
Is urotensin-II the new endothelin?
Maguire and Davenport
Br.J.Pharmacol, 2002;137:579
Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction.
Nothacker et al.
Nat.Cell.Biol., 1999;1:383

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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