Vigabatrin
Chemical Name: 4-Aminohexenoic acid
Purity: ≥98%
Biological Activity
Vigabatrin is a selective GABA-T (transaminase) inhibitor. Anticonvulsant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes.
Larsson et al.
Neuropharmacology, 1986;25:617 -
Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon.
Schmid et al.
J.Pharmacol.Exp.Ther., 1996;276:977 -
Effects of vigab. (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats.
Halonen et al.
Epilepsia, 1991;32:242
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Citations for Vigabatrin
The citations listed below are publications that use Tocris products. Selected citations for Vigabatrin include:
2 Citations: Showing 1 - 2
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Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use-limiting visual field defects.
Authors: Walters Et al.
Pharmacol Res Perspect 2019;7:e00456
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Glutamate uptake triggers transporter-mediated GABA release from astrocytes.
Authors: Héja Et al.
Stem Cells Dev 2009;4:e7153
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