VU 0155041

Name: VU 0155041
Brand: Tocris Bioscience
SKU: 3248
Price: 61 USD

Catalog #: 3248
3 Citations Datasheet / COA / SDS

Discontinued Product

3248 has been discontinued.

View all Group III mGluR Agonists products.

VU 0155041 | CAS No. 1093757-42-6 | Group III mGluR Agonists

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Description: Potent positive allosteric modulator of mGlu4 receptors

Chemical Name: cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid

Purity: ≥99%

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Product Details

Citations (3)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VU 0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu₄ receptors (EC₅₀ = 798 and 693 nM at human and rat mGlu₄ receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Also available as sodium salt (Cat. No. 3311).

Technical Data

M.Wt:

316.18

Formula:

C₁₄H₁₅Cl₂NO₃

Solubility:

Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at RT

CAS No:

1093757-42-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Niswender et al.
Mol.Pharmacol., 2008;74:1345

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for VU 0155041

The citations listed below are publications that use Tocris products. Selected citations for VU 0155041 include:

3 Citations: Showing 1 - 3

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (
Authors: Jones Et al.
J Med Chem 2011;54:7639
Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges.
Authors: Duvoisin Et al.
Behav Brain Res 2011;221:50
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
Authors: Williams Et al.
Bioorg Med Chem Lett 2009;19:4967

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