Home / mAChR M1 Modulators / VU 0357017 hydrochloride

VU 0357017 hydrochloride

Catalog #: 4295
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4295/10
4295/50
VU 0357017 hydrochloride | CAS No. 1135242-13-5 | mAChR M1 Modulators
1 Image
Description: Positive allosteric modulator of M1 receptors

Chemical Name: 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VU 0357017 hydrochloride is a positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.

Technical Data

M.Wt:
369.89
Formula:
C18H27N3O3.HCl
Solubility:
Soluble to 25 mM in water and to 5 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1135242-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM.
    Bridges et al.
    Bioorg.Med.Chem.Lett., 2010;20:1972
  2. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system.
    Lebois et al.
    ACS Chem.Neurosci., 2010;1:104

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for VU 0357017 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for VU 0357017 hydrochloride include:

3 Citations: Showing 1 - 3

  1. Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex.
    Authors: Pasko Et al.
    Neuron  2020;106:649-661.e4
  2. Muscarinic M1 Receptor Overstimulation Disrupts Working Memory Activity for Rules in Primate Prefrontal Cortex.
    Authors: Stefan Et al.
    Neuron  2018;98:1256-1268.e4
  3. Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress.
    Authors: Jadeja Et al.
    J Am Soc Nephrol  2016;6:405

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for VU 0357017 hydrochloride

There are currently no reviews for this product. Be the first to review VU 0357017 hydrochloride and earn rewards!

Have you used VU 0357017 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.