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VU 590 dihydrochloride

Catalog #: 3891
2 Citations Datasheet / COA / SDS

Discontinued Product

3891 has been discontinued.
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VU 590 dihydrochloride | CAS No. 1783987-83-6 | Inward Rectifier Potassium Channel Blockers
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Description: Inhibitor of Kir1.1 (ROMK) and Kir7.1

Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.

Technical Data

M.Wt:
561.46
Formula:
C24H32N4O7.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1783987-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for VU 590 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for VU 590 dihydrochloride include:

2 Citations: Showing 1 - 2

  1. The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.
    Authors: Yin Et al.
    Nat Commun  2018;9:2815
  2. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
    Authors: Bhave Et al.
    Mol Pharmacol  2011;79:42

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