Home / mAChR M4 Antagonists / VU 6028418 hydrochloride

VU 6028418 hydrochloride

Catalog #: 7658 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7658/10
7658/50
VU 6028418 hydrochloride | mAChR M4 Antagonists
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Description: Potent and selective M4 mAChR antagonist

Chemical Name: (3aR,5s,6aS)-2-((Tetrahydro-2H-pyran-4-yl)methyl)-N-(6-(2,3,5-trifluorophenyl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine hydrochloride

Purity: ≥98%

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Biological Activity

VU 6028418 hydrochloride is a potent and selective M4 mAChR antagonist (IC50 = 4.1 nM and 57 nM for human and rat M4 respectively). VU 6028418 hydrochloride dose-dependently reduces the latency to withdraw and reverses cataleptic behavior in haloperidol-treated animals. Orally bioavailable.

Technical Data

M.Wt:
468.95
Formula:
C23H27F3N4O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Vanderbilt University

Product Datasheets

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